Fiber-Mediated Nourishment of Gut Microbiota Protects against Diet-Induced Obesity by Restoring IL-22-Mediated Colonic Health

Researchers at Georgia State University, in an article published in Cell Host & Microbe, have found that in mice, fermentable fiber (specifically inulin in this case) protects against metabolic syndrome by nourishing microbiota to restore IL-22-mediated enterocyte function, without involving fiber-derived short-chain fatty acids (SCFAs), which had been previously thought to be the mechanism.