According to an article published in the journal Nutrients, researchers at Hokkaido Information University examined the impact of consumption of a prebiotic yeast mannan (Five tablets, equivalent to a daily dose, contained 1.1 g of yeast mannan, and these were confirmed to contain 0.62 g of mannan) on gut health and sleep quality on healthy adults in a randomized, double-blind, placebo-controlled study. They observed increased defecation frequency and stool volumes compared to the placebo group, several metabolite differences as well as changes in fecal propionate and gamma-aminobutyric acid (GABA) levels.

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